منابع مشابه
Challenges of antiangiogenic cancer therapy: trials and errors, and renewed hope
Angiogenesis inhibition has been proposed as a general strategy to fight cancer. However, in spite of the promising preclinical results, a first generation of antiangiogenic compounds yielded poor results in clinical trials. Conceptual errors and mistakes in the design of trials and in the definition of clinical end-points could account for these negative results. In this context of discouragin...
متن کاملEvaluation of Clinical Trials
In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...
متن کاملSpecial Report Drug Therapies for the Primary Prevention of Cardiovascular Events: Trials and Errors
I am grateful to the Epidemiology and Prevention Council for the honor and the opportunity to speak today. Henry Blackburn entitled his introduction to the first Ancel Keys lecture “Ancel Keys, pioneer” and summarized Keys’ astonishing array of work in nutrition and physiology, methods, and prevention, including the diet-heart hypothesis and efforts to bridge biology, preventive medicine, and p...
متن کاملEvidence Based Medicine: Clinical Trials
Evidence based medicine is very important for success of modern medicine. It is the ongoing process of using the most reliable evidence from clinical studies, scientific understanding and medical practice to make the best possible medical choice for patients. Evidence based medicine is how medicine advances and how we get improvements in life expectancy and quality of life. It not only identifi...
متن کاملSoft Errors and Tolerance for Soft Errors
IC technologies are approaching the ultimate limits of silicon in terms of channel width, power supply and speed. By approaching these limits, circuits are becoming increasingly sensitive to noise. The reduction of VDD voltage and geometry shrinking implies the reduction of node capacitance. This will increase the ICs sensitivity to alpha particles and atmospheric neutrons, creating unacceptabl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 1998
ISSN: 0028-0836,1476-4687
DOI: 10.1038/25644